The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities

Frontiers in Pediatrics

Kathrin M. Bernt¹ 

关键词: leukemia;    lymphoid;    epigenetics;    polycomb repressive complex;    Hox genes;    JAK/STAT signaling pathway;   

DOI  :  10.3389/fped.2016.00049

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients.

【 授权许可】

CC BY