Evaluation of the response to vaccination with hepatitis B vaccine in pediatric patients diagnosed with celiac disease:

SAGE Open Medicine

DorotaWalkiewicz-Jedrzejczak¹ 

关键词: Celiac disease;    pediatrics;    vaccination;   

DOI  :  10.1177/2050312114563346

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:A gap exists in the literature on celiac disease populations and the response to hepatitis B vaccination.Objective:To identify pediatric patients with celiac disease who received the primary hepatitis B vaccination and investigate their response to vaccine.Design/Methods:Patients underwent blood draw for hepatitis B surface antibody titers. Patients with undetectable or non-protective HBsAb titers were contacted. Study outcome measures and patient characteristics variables were summarized by means, standard deviations, medians, and ranges. A two-sample t-test was used to compare normally distributed continuous variables between responders and non-responders.Results:In all, 58% of patients did not meet the threshold for “protective” antibody titers. The mean time between completion of hepatitis B vaccination and diagnosis of celiac disease was 8.1 years for responders versus 10.5 years for non-responders. In a multivariate analysis, time between completion of vaccine and diagnosis of celiac dise...

【 授权许可】

CC BY