Metabolic Linkage and Correlations to Storage Capacity in Erythrocytes from Glucose 6-Phosphate Dehydrogenase-Deficient Donors

Frontiers in Medicine

Julie A. Reisz¹ 

关键词: glucose 6-phosphate dehydrogenase deficiency;    transfusion medicine;    red blood cell storage lesion;    donor variation;    mass spectrometry;    metabolomics;    interactome;   

DOI  :  10.3389/fmed.2017.00248

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

ObjectiveIn glucose 6-phosphate dehydrogenase (G6PD) deficiency, decreased NADPH regeneration in the pentose phosphate pathway and subnormal levels of reduced glutathione result in insufficient antioxidant defense, increased susceptibility of red blood cells (RBCs) to oxidative stress, and acute hemolysis following exposure to pro-oxidant drugs and infections. Despite the fact that redox disequilibrium is a prominent feature of RBC storage lesion, it has been reported that the G6PD-deficient RBCs store well, at least in respect to energy metabolism, but their overall metabolic phenotypes and molecular linkages to the storability profile are scarcely investigated.

【 授权许可】

CC BY