Diagnostic Test Accuracy of Serum Anti-PLA2R Autoantibodies and Glomerular PLA2R Antigen for Diagnosing Idiopathic Membranous Nephropathy: An Updated Meta-Analysis

Frontiers in Medicine

Weiying Li¹ 

关键词: membranous nephropathy;    M-type phospholipase A2 receptor;    anti-phospholipase A2 receptor;    diagnostic test accuracy;    secondary membranous nephropathy;    sPLA2R;    gPLA2R;   

DOI  :  10.3389/fmed.2018.00101

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

BackgroundM-type phospholipase A2 receptor (PLA2R) is known as a major antigen on podocytes, which is involved with the pathogenesis of idiopathic membranous nephropathy (iMN). Many studies have shown that serum anti-PLA2R autoantibodies (sPLA2R) are prevalent in patients with iMN but are rarely detected in secondary membranous nephropathy (SMN) or other glomerulonephritis. The anti-PLA2R is considered as a promising serum biomarker in iMN but reports about its diagnostic value are variable and inconsistent.

【 授权许可】

CC BY