Quantitative Ex Vivo MRI Changes due to Progressive Formalin Fixation in Whole Human Brain Specimens: Longitudinal Characterization of Diffusion, Relaxometry, and Myelin Water Fraction Measurements at 3T

Frontiers in Medicine

Anwar S. Shatil¹ 

关键词: ex vivo;    fixation;    formalin;    longitudinal;    postmortem;    human brain;    MRI;    myelin;    diffusion;    T1;    T2;   

DOI  :  10.3389/fmed.2018.00031

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

PurposePostmortem MRI can be used to reveal important pathologies and establish radiology–pathology correlations. However, quantitative MRI values are altered by tissue fixation. Therefore, the purpose of this study was to investigate time-dependent effects of formalin fixation on MRI relaxometry (T1 and T2), diffusion tensor imaging (fractional anisotropy, FA; and mean diffusivity, MD), and myelin water fraction (MWF) measurements throughout intact human brain specimens.

【 授权许可】

CC BY