Obesity, Inflammation and Neurological Alterations:

European Journal of Inflammation

E.Spinas¹ 

关键词: obesity;    inflammation;    cholesterol;    mast cells;   

DOI  :  10.1177/1721727X1401200302

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Inflammation, neurodegeneration, imbalance of neurotransmitter systems, oxidative stress and depression are all risk factors for obesity. There is evidence regarding the cross-talk between adipose tissue and the immune system and obese patients may show an alteration of immune functions with major depression, including immune suppression with reduced T-cell and macrophage activity. Obesity is mediated by inflammatory cells such as lymphocytes, macrophages and mast cells which release pro-inflammatory cytokines and chemokines. Obesity-induced leukocyte infiltrations in adipose tissue cause cytokine/chemokine release and inflammation. Here, we report the relationship between obesity, neurological alterations and inflammation.

【 授权许可】

CC BY-NC