Relationship between Sperm Hyaluronan-Binding Assay (HBA) Scores on Embryo Development, Fertilisation, and Pregnancy Rate in Patients Undergoing Intra-Cytoplasmic Sperm Injection (ICSI):

Proceedings of Singapore Healthcare

Carine To ChiouFen¹ 

关键词: Chromosomal abnormalities;    DNA integrity;    Sperm plasma membrane remodelling;   

DOI  :  10.1177/201010581302200207

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Introduction:The novel development of the sperm hyaluronan-binding assay (HBA) has now been routinely used in some laboratories worldwide to predict sperm maturity and functionality. Hence, the purpose of this study is to evaluate if embryo development, quality, fertilisation and pregnancy rates are affected by low HBA values.Methods:A total of192 female patients who underwent intra-cytoplasmic sperm injection (ICSI) were compared retrospectively in terms of embryo development, fertilisation, and pregnancy rates with their husbands' HBA score. Patients' husbands were required to undergo a HBA test before the start of their stimulation cycle to determine if their semen was suitable to undergo ICSI or in-vitro fertilisation (IVF). P-value < 0.05 was considered significant.Results:Patients were divided into four groups, group A (HBA ≤ 15%), group B (HBA > 15% < 35%), group C (HBA ≥ 35% < 60%), and group D (HBA ≥ 60%). The fertilisation rate for groups A, B, C, and D were 67.9%, 73.1%, 72.5%, and 77.1% respec...

【 授权许可】

CC BY