Metabolic recoding of epigenetics in cancer

Cancer Communications

Qun-Ying Lei¹  Yi-Ping Wang¹ 

[1] Cancer Institute, Fudan University Cancer Hospital and Cancer Metabolism Laboratory, Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China

关键词: Cancer metabolism;    Epigenetics;    Metabolites;    Histone modification;    DNA methylation;    Cancer microenvironment;    Nutrient availability;   

DOI  :  10.1186/s40880-018-0302-3

学科分类：肿瘤学

来源: Springer

【 摘 要 】

Dysregulation of metabolism allows tumor cells to generate needed building blocks as well as to modulate epigenetic marks to support cancer initiation and progression. Cancer-induced metabolic changes alter the epigenetic landscape, especially modifications on histones and DNA, thereby promoting malignant transformation, adaptation to inadequate nutrition, and metastasis. Recent advances in cancer metabolism shed light on how aberrations in metabolites and metabolic enzymes modify epigenetic programs. The metabolism-induced recoding of epigenetics in cancer depends strongly on nutrient availability for tumor cells. In this review, we focus on metabolic remodeling of epigenetics in cancer and examine potential mechanisms by which cancer cells integrate nutritional inputs into epigenetic modification.

【 授权许可】

CC BY