Commentary: Impact of Fecal Calprotectin Measurement on Decision-Making in Children with Inflammatory Bowel Disease

Frontiers in Pediatrics

Andrew S. Day¹ 

关键词: children;    inflammatory bowel disease;    fecal markers;    calprotectin;    Crohn disease;   

DOI  :  10.3389/fped.2017.00133

学科分类：儿科学

来源: Frontiers

【 摘 要 】

In their recent publication, El-Matary et al. (1) describe the utility of measurement of fecal calprotectin (FC) in the ongoing management of children with known inflammatory bowel disease (IBD). In this cohort of 77 children, FC was measured upon presentation with key changes in symptoms (most commonly abdominal pain and hematochezia). The child’s management was then adjusted according to the level of the FC, with a cutoff of 250 µg/g stool. Almost 90% of those with elevated FC had a change in their management, which resulted in a reduction in clinical activity indices over the subsequent 3–6 months. Repeated FC measurements were not available. Conversely, the majority of those with low FC (below the cutoff) had no change in management in the following months. Reassuringly, 94% of these children were judged to be in remission at their follow-up visit.

【 授权许可】

CC BY