The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models

Animal Models and Experimental Medicine

Shu‐¹  ran Gong¹ 

[1] Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center Peking Union Medical College (PUMC) Key Laboratory of Human Disease Comparative Medicine Ministry of Health Key Laboratory for Animal Models of Emerging and Reemerging Infectious Beijing China

关键词: animal models;    coronaviruses;    reservoirs;    the Middle East respiratory syndrome (canonical form);    the severe acute respiratory syndrome;   

DOI  :  10.1002/ame2.12017

学科分类：医学（综合）

来源: Wiley

【 摘 要 】

In humans, infection with the coronavirus, especially the severe acute respiratory syndrome coronavirus (SARS‐CoV) and the emerging Middle East respiratory syndrome coronavirus (MERS‐CoV), induces acute respiratory failure, resulting in high mortality. Irregular coronavirus related epidemics indicate that the evolutionary origins of these two pathogens need to be identified urgently and there are still questions related to suitable laboratory animal models. Thus, in this review we aim to highlight key discoveries concerning the animal origin of the virus and summarize and compare current animal models.

【 授权许可】

CC BY