BLTR1 and CD36 Expressing Microvesicles in Atherosclerotic Patients and Healthy Individuals

Frontiers in Cardiovascular Medicine

Mathilde S¹ 

关键词: atherosclerosis;    extracellular vesicles;    microvesicles;    BLT1;    flow cytometry;    arachidonic acid;    eicosapentaenoic acid;    leukotriene b4 receptor;   

DOI  :  10.3389/fcvm.2018.00156

学科分类：心脏病和心血管学

来源: Frontiers

【 摘 要 】

Aims: Monocytes/macrophages play a crucial role in the development, progression, and complication of atherosclerosis. In particular, foam cell formation driven by CD36 mediated internalization of oxLDL leads to activation of monocytes and subsequent release of microvesicles (MVs) derived from monocytes (MMVs). Further, pro-inflammatory leukotriene B4 (LTB4) derived from arachidonic acid promotes atherosclerosis through the high-affinity receptor BLTR1. Thus, we aimed to investigate the correlation between different MMV phenotypes (CD14+ MVs) on the one hand, and arachidonic acid and eicosapentaenoic acid contents in different compartments including atherosclerotic plaques, plasma, and granulocytes on the other.

【 授权许可】

CC BY