Assessment of a novel cryoablation device for the endovascular treatment of cardiac tachyarrhythmias:

SAGE Open Medicine

John MBaust¹ 

关键词: Cryoablation;    supercritical nitrogen;    atrial fibrillation;    catheter ablation;   

DOI  :  10.1177/2050312118769797

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objectives:Cryoablation is an effective alternative treatment for cardiac arrhythmias offering shortened recovery and reduced side effects. As the use of cryoablation increases, the need for new devices and procedures has emerged. This has been driven by technological limitations including lengthy periods to generate a single lesion (3–5 min), uncertain transmurality, and differential efficacy. Furthermore, due to limited ablation capacity under high heat loads, cryo has had limited success in the treatment of ventricular arrhythmias. To this end, in this study we evaluated a new cryoablation catheter, ICEolate, for the targeted ablation of cardiac tissue.Methods:Performance assessment included calorimetry, freeze zone isothermal distribution characterization and catheter ablation capacity in a submerged, circulating, heat-loaded ex vivo tissue model. A pilot in vivo study was also conducted to assess ablative capacity of the cryocatheter in a fully beating heart.Results:Ex vivo studies demonstrated ice f...

【 授权许可】

CC BY