Frontiers in Medicine | |
Complement in Kidney Transplantation | |
Marek Cernoch1  | |
关键词: complement; kidney transplantation; antibody-mediated rejection; ischemia/reperfusion injury; anticomplement therapy; | |
DOI : 10.3389/fmed.2017.00066 | |
学科分类:医学(综合) | |
来源: Frontiers | |
【 摘 要 】
The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or lectin pathway, resulting in the creation of anaphylatoxins C3a and C5a, possessing a vast spectrum of immune functions, and the assembly of terminal complement cascade, capable of direct cell lysis. The activation processes are tightly regulated; inappropriate activation of the complement cascade plays a significant role in many renal diseases including organ transplantation. Moreover, complement cascade is activated during ischemia/reperfusion injury processes and influences delayed graft function of kidney allografts. Interestingly, complement system has been found to play a role in both acute cellular and antibody-mediated rejections and thrombotic microangiopathy. Therefore, complement system may represent an interesting therapeutical target in kidney transplant pathologies.
【 授权许可】
CC BY
【 预 览 】
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RO201901223076239ZK.pdf | 632KB | download |