What is the effect of nicotinic acetylcholine receptor stimulation on osteoarthritis in a rodent animal model?:

SAGE Open Medicine

KilianBock¹ 

关键词: Osteoarthritis;    monoiodoacetate;    metalloproteases;    cytokines;    inflammation;    nicotine;   

DOI  :  10.1177/2050312116637529

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objectives:Despite the rising number of patients with osteoarthritis, no sufficient chondroprotective and prophylactic therapy for osteoarthritis has been established yet. The purpose of this study was to verify whether stimulation of the nicotinic acetylcholine receptor via nicotine has a beneficial effect on cartilage degeneration in the development of osteoarthritis and is capable of reducing the expression of proinflammatory cytokines and cartilage degrading enzymes in synovial membranes after osteoarthritis induction.Methods:Experimental osteoarthritis was induced in Lewis rats using a standardized osteoarthritis model with monoiodoacetate. A total of 16 Lewis rats were randomized into four groups: control, sham + nicotine application, osteoarthritis, and osteoarthritis + nicotine application. Nicotine (0.625 mg/kg twice daily) was administered intraperitoneally for 42 days. We analyzed histological sections, radiological images and the expression of the proinflammatory cytokines, such as interleukin...

【 授权许可】

CC BY