Tracing evolutionary relicts of positive selection on eight malaria-related immune genes in mammals:

Innate Immunity

Bing-HongHuang¹ 

关键词: Eutherian;    evolutionary arms race;    functional divergence;    immunogenes;    malaria;    Plasmodium;    positive selection;    recombination;   

DOI  :  10.1177/1753425914547744

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Plasmodium-induced malaria widely infects primates and other mammals. Multiple past studies have revealed that positive selection could be the main evolutionary force triggering the genetic diversity of anti-malaria resistance-associated genes in human or primates. However, researchers focused most of their attention on the infra-generic and intra-specific genome evolution rather than analyzing the complete evolutionary history of mammals. Here we extend previous research by testing the evolutionary link of natural selection on eight candidate genes associated with malaria resistance in mammals. Three of the eight genes were detected to be affected by recombination, including TNF-α, iNOS and DARC. Positive selection was detected in the rest five immunogenes multiple times in different ancestral lineages of extant species throughout the mammalian evolution. Signals of positive selection were exposed in four malaria-related immunogenes in primates: CCL2, IL-10, HO1 and CD36. However, selection signals of G6...

【 授权许可】

CC BY