Mesenchymal Stromal Cell Dependent Regression of Pulmonary Metastasis from Ewing’s

Frontiers in Pediatrics

Andrea Hayes-Jordan¹ 

关键词: stem cell;    Ewings sarcoma;    lung metastases;    pediatrics;    murine model;    mesenchymal stromal cells;   

DOI  :  10.3389/fped.2014.00044

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Introduction: Ewing’s sarcoma (ES) is the second most common bone tumor in children. Survival has not improved over the last decade and once pulmonary metastatic disease is present, survival is dismal. Mesenchymal stromal cell (MSC) therapy has shown potential benefit for Kaposi’s sarcoma; however, the role of progenitor cell therapies for cancer remains controversial. MSC treatment of ES or pulmonary metastatic disease has not been demonstrated. We have developed an orthotopic xenograft model of ES in which animals develop spontaneous pulmonary metastases. Within this model, we demonstrate the use of MSCs to target ES lung metastasis.

【 授权许可】

CC BY