Single nucleotide polymorphism –799C/T in matrix metalloproteinase-8 promoter region in arterial disease:

Innate Immunity

PratikshyaPradhan-Palikhe¹ 

关键词: Arterial disease;    human DNA;    matrix metalloproteinase-8;    serum;    single nucleotide polymorphism;   

DOI  :  10.1177/1753425911423852

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Arterial disease is associated with elevated serum matrix metalloproteinase (MMP)-8 concentration. We studied the role of two promoter region single nucleotide polymorphisms (SNPs) of MMP-8 gene in the arterial disease. The population comprised patients with arterial disease (n = 124) and healthy blood donors (n = 100) as a reference group for MMP-8 SNPs (−799C/T and −381A/G) genotypes and serum concentrations. Genotype frequencies for MMP-8 −799C/T SNP in arterial disease were C/C (43.5%), C/T (32.3%) and T/T (24.2%), and in the reference group they were C/C (50.0%), C/T (40.0%) and T/T (10.0%; P = 0.012). The −799C allele frequency was lower in the patients (59.7%) than in the reference group (70.0%; P = 0.023). The −799C allele showed protective effects against the arterial disease with an odds ratio [95% confidence interval (CI)] of 0.372 (0.141–0.980, P = 0.045) after adjustment for age, gender, and serum MMP-8 and TIMP-1 concentrations. Only in the reference group and whole study population (n = 224...

【 授权许可】

CC BY