Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery

Frontiers in Cardiovascular Medicine

Michael J. Greenberg¹ 

关键词: heart failure;    tissue engineering;    length-tension relationship;    gene editing;    human induced pluripotent stem cells;    high-throughput screening;    rare heart disease;    drug discovery;   

DOI  :  10.3389/fcvm.2018.00120

学科分类：心脏病和心血管学

来源: Frontiers

【 摘 要 】

Heart failure is the leading cause of death in the western world and as such, there is a great need for new therapies. Heart failure has a variable presentation in patients and a complex etiology; however, it is fundamentally a condition that affects the mechanics of cardiac contraction, preventing the heart from generating sufficient cardiac output under normal operating pressures. One of the major issues hindering the development of new therapies has been difficulties in developing appropriate in vitro model systems of human heart failure that recapitulate the essential changes in cardiac mechanics seen in the disease. Recent advances in stem cell technologies, genetic engineering, and tissue engineering have the potential to revolutionize our ability to model and study heart failure in vitro. Here, we review how these technologies are being applied to develop personalized models of heart failure and discover novel therapeutics.

【 授权许可】

CC BY