The historical association between measles and pertussis: A case of immune suppression?:

SAGE Open Medicine

StephenColeman¹ 

关键词: Epidemics;    pertussis;    measles;    whooping cough;    immune suppression;    historical;    United States;   

DOI  :  10.1177/2050312115621315

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objectives:According to historical medical reports, many children with measles subsequently contracted pertussis, often with fatal results. The likelihood of a child contracting pertussis after a measles infection is increased by its immune-suppressing effects. This research aims to verify the historical reports.Methods:The analysis examines statistically the historical relationship between average measles and pertussis incidence rates in the United States from 1938 to 1954 at the state level and in average weekly rates. Analysis of incidence rates is cross-sectional at the state level using public health data.Results:The results show that, on average and over time, states with higher measles rates have higher pertussis rates, and the peaks and nadirs of average weekly incidence rates of pertussis lag measles by a delay of about 3–4 weeks, well within the duration of immune suppression. Measles and pertussis have similar geographical distributions.Conclusion:The research tentatively supports the hypothesi...

【 授权许可】

CC BY