Effects of Lycium barbarum on bacterial translocation in thioacetamide-induced liver injury in rats:

European Journal of Inflammation

YBilgic¹ 

关键词: bacterial translocation;    liver injury;    Lycium barbarum;    thioacetamide;   

DOI  :  10.1177/1721727X15618413

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background and study aim:The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats.Materials and methods:Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum.Results:In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency.Conclusions:In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.

【 授权许可】

CC BY-NC