Homozygosity for the SCN10A Polymorphism rs6795970 Is Associated With Hypoalgesic Inflammatory Bowel Disease Phenotype

Frontiers in Medicine

Eugene Gonzalez-Lopez¹ 

关键词: genetic polymorphism;    inflammatory bowel disease;    voltage-gated sodium channels;    Nav1.8;    SCN10A;    hypoalgesia;    abdominal pain;   

DOI  :  10.3389/fmed.2018.00324

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Background: Hypoalgesic inflammatory bowel disease (IBD), a condition in which patients with active disease do not perceive and/or report abdominal pain, is associated with serious complications and there is a lack of cost-effective, reliable diagnostic methods to identify “at-risk” patients. The voltage-gated sodium channels (VGSC's), Nav1.7, Nav1.8, and Nav1.9, are preferentially expressed on nociceptive neurons, and have been implicated in visceral inflammatory pain. At least 29 VGSC single nucleotide polymorphisms (SNPs) have been implicated in chronic somatic pain syndromes, but little is known about their role in human visceral sensation. We hypothesized that disruptive VGSC polymorphisms result in anti-nociceptive behavior in IBD.

【 授权许可】

CC BY