Clinical and genetic determinants of nevirapine plasma trough concentration:

SAGE Open Medicine

AndreaGiacomelli¹ 

关键词: Nevirapine;    pharmacogenetic;    CYP2B6;    plasma concentrations;   

DOI  :  10.1177/2050312118780861

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:Only few data are available on the influence of CYP2B6 and CYP3A4/A5 polymorphisms on nevirapine plasma concentrations in the Caucasian population. Our aim was to assess the impact of CYP2B6 and CYP3A4/A5 polymorphisms on nevirapine plasma concentrations consecutively collected.Methods:We retrospectively analyzed clinical data of all HIV-positive patients who were followed at the Infectious Diseases Unit, DIBIC Luigi Sacco, University of Milan between January 2000 and December 2015. All patients with at least one nevirapine plasma trough concentration (NVP Cmin) determination were tested for CYP2B6 c.516 G>T, CYP3A4*22C>T and CYP3A5*3 A>G polymorphisms. Univariate and multivariate regression analyses were carried out considering NVP Cmin as the dependent variable and genetic polymorphisms and clinical characteristics as independent variables.Results:A total of 143 patients were evaluated. Most of them were males (61.5%) and Caucasian (92.3%). Overall, NVP Cmin varied from 1571 to 14,189  ng/mL ...

【 授权许可】

CC BY