Review: Gp-340/DMBT1 in mucosal innate immunity:

Innate Immunity

JensMadsen¹ 

关键词: innate immunity;    mucosal;    deleted in malignant brain tumour 1;    DMBT1;    collectin;    surfactant protein D;   

DOI  :  10.1177/1753425910368447

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Deleted in Malignant Brain Tumour 1 (DMBT1) is a gene that encodes alternatively spliced proteins involved in mucosal innate immunity. It also encodes a glycoprotein with a molecular mass of 340 kDa, and is referred to as gp-340 (DMBT1gp340) and salivary agglutinin (DMBT1SAG). DMBT1gp340 is secreted into broncho-alveolar surface lining fluid whereas DMBTSAG is present in the saliva. The two molecules were shown to be identical and both interact with and agglutinate several Gram-negative and Gram-positive bacteria including Streptococcus mutans, a bacterium responsible for caries in the oral cavity. DMBT1gp340 interacts with surfactant proteins A and D (SP-D). DMBT1gp340 and SP-D can individually and together interact and agglutinate influenza A virus. DMBT1gp340 also binds to HIV-1 and facilitates transcytosis of the virus into epithelial cells. DMBT1 binds to a variety of other host proteins, including serum and secretory IgA, C1q, lactoferrin, MUC5B and trefoil factor 2 (TFF2), all molecules with involv...

【 授权许可】

CC BY