Innate Immunity | |
Review: Gp-340/DMBT1 in mucosal innate immunity: | |
JensMadsen1  | |
关键词: innate immunity; mucosal; deleted in malignant brain tumour 1; DMBT1; collectin; surfactant protein D; | |
DOI : 10.1177/1753425910368447 | |
学科分类:生物科学(综合) | |
来源: Sage Journals | |
【 摘 要 】
Deleted in Malignant Brain Tumour 1 (DMBT1) is a gene that encodes alternatively spliced proteins involved in mucosal innate immunity. It also encodes a glycoprotein with a molecular mass of 340 kDa, and is referred to as gp-340 (DMBT1gp340) and salivary agglutinin (DMBT1SAG). DMBT1gp340 is secreted into broncho-alveolar surface lining fluid whereas DMBTSAG is present in the saliva. The two molecules were shown to be identical and both interact with and agglutinate several Gram-negative and Gram-positive bacteria including Streptococcus mutans, a bacterium responsible for caries in the oral cavity. DMBT1gp340 interacts with surfactant proteins A and D (SP-D). DMBT1gp340 and SP-D can individually and together interact and agglutinate influenza A virus. DMBT1gp340 also binds to HIV-1 and facilitates transcytosis of the virus into epithelial cells. DMBT1 binds to a variety of other host proteins, including serum and secretory IgA, C1q, lactoferrin, MUC5B and trefoil factor 2 (TFF2), all molecules with involv...
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201901221270412ZK.pdf | 372KB | download |