Proteomic and transcriptomic analyses to explain the pleiotropic effects of Ankaferd blood stopper:

SAGE Open Medicine

CemSimsek¹ 

关键词: Ankaferd blood stopper;    hemostasis;    proteomic analysis;    genomic analysis;    pleiotropic effect;   

DOI  :  10.1177/2050312117722569

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Ankaferd blood stopper is a standardized mixture of the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica and has been used as a topical hemostatic agent and with its clinical application established in randomized controlled trials and case reports. Ankaferd has been successfully used in gastrointestinal endobronchial mucosal and cutaneous bleedings and also in abdominal, thoracic, dental and oropharyngeal, and pelvic surgeries. Ankaferd’s hemostatic action is thought to form a protein complex with coagulation factors that facilitate adhesion of blood components. Besides its hemostatic action, Ankaferd has demonstrated pleiotropic effects, including anti-neoplastic and anti-microbial activities and tissue-healing properties; the underlying mechanisms for these have not been well studied. Ankaferd’s individual components were determined by proteomic and chemical analyses. Ankaferd also augments transcription of some transcription factors which is shown with ...

【 授权许可】

CC BY