期刊论文详细信息
Frontiers in Public Health
The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage
Quan Zou1 
关键词: allele identical by descent;    ITO method;    quantitative trait locus;    relative pairs;    linkage analysis;   
DOI  :  10.3389/fpubh.2016.00259
学科分类:卫生学
来源: Frontiers
PDF
【 摘 要 】

I introduce a novel approach to derive the distribution of disease affectional status given alleles identical by descent (IBD) sharing through ITO method. My approach tremendously simplifies the calculation of the affectional status distribution compared to the conventional method, which requires the parental mating information, and could be applied to disease with both dichotomous trait and quantitative trait locus (QTL). This distribution is shown to be independent of relative relationship and be employed to develop the marker IBD distributions for relative relationship. In addition, three linkage tests: the proportion, the mean test, and the LOD score test are proposed for different relative pairs based on their marker IBD distributions. Among all three tests, the mean test for sib pair requires the least sample size, thus, has the highest power. Finally, I evaluate the significance of different relative relationships by a Monte-Carlo simulation approach.

【 授权许可】

CC BY   

【 预 览 】
附件列表
Files Size Format View
RO201901220707798ZK.pdf 1027KB PDF download
  文献评价指标  
  下载次数:2次 浏览次数:11次