Anti-High-Density Lipoprotein Antibodies and Antioxidant Dysfunction in Immune-Driven Diseases

Frontiers in Medicine

Javier Rodríguez-Carrio¹ 

关键词: anti-HDL;    autoantibodies;    high-density lipoprotein;    antioxidant;    autoimmunity;    cardiovascular;   

DOI  :  10.3389/fmed.2018.00114

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

IntroductionImpaired high-density lipoprotein (HDL) levels and antioxidant functionality of HDL, mainly attributed to a decreased paraoxonase-1 (PON1) functionality, have been described in autoimmune conditions. In this setting, a role for humoral response in cardiovascular disease is emerging. This study evaluates the role of immunoglobulin G (IgG) antibodies against HDL and disease-related autoantibodies on HDL dysfunction in immune-driven diseases.

【 授权许可】

CC BY