Improvement of the Targeting of Radiolabeled and Functionalized Liposomes with a Two-Step System Using a Bispecific Monoclonal Antibody (Anti-CEA × Anti-DTPA–In)

Frontiers in Medicine

Aurore Rauscher¹ 

关键词: pegylated liposomes;    radioimmunotherapy;    bispecific antibody;    pretargeting;    solid tumors;   

DOI  :  10.3389/fmed.2015.00083

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

This study proposes liposomes as a new tool for pretargeted radioimmunotherapy (RIT) in solid tumors. Tumor pretargeting is obtained by using a bispecific monoclonal antibody [BsmAb, anti-CEA × anti-DTPA-indium complex (DTPA–In)] and pegylated radioactive liposomes containing a lipid-hapten conjugate (DSPE–PEG–DTPA–In). In this work, the immunospecificity of tumor targeting is demonstrated both in vitro by fluorescence microscopy and in vivo by biodistribution studies.

【 授权许可】

CC BY