Editorial: Interaction of Gas Messengers With Mitochondria in Health and Disease

Frontiers in Medicine

Andrey V. Kozlov¹ 

关键词: nitric oxide;    carbone monoxide distribution;    hydrogen sulfide (H 2S);    methane;    mitochondria;   

DOI  :  10.3389/fmed.2018.00259

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Since a decade three gases nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are recognized as being produced by eukaryotic cells to serve as messengers in intracellular signaling pathways. More recently methane (CH4) was recognized as the 4th gas messenger. All four gases not only act in a defined range of physiological processes, but also contribute to the development of a number of diseases. All four gas messengers exert similar biological effects and have similar target structures. One of the most important target structures for all four gaseous mediators are mitochondria. Mitochondria are relatively autonomous intracellular organelle in eukaryotic cells. They regulate many essential intracellular processes such as energy supply, reactive oxygen species mediated signaling, oxidative stress, programmed cell death, turnover of Ca2+, several metabolic pathways related to lipid and protein metabolism. It is less clear how mitochondrial functions are regulated from the up-stream side and how up-stream regulatory signaling pathways are transformed by mitochondria into down-stream physiological and pathological manifestations of health and diseases. Endogenous gaseous messengers, NO, CO, H2S, CH4 are known to have a high affinity to different segments of mitochondria and are able to modulate efficiently mitochondrial functions. This suggests that endogenous gas messengers may orchestrate a reach pallet of pathways mediated by mitochondria.

【 授权许可】

CC BY