ГЕНЕТИЧЕСКИЕ ПРЕДИКТОРЫ ТЯЖЕЛОГО ОСЛОЖНЕННОГО ГРИППА A(H1N1) У БЕРЕМЕННЫХ

Acta Biomedica Scientifica

Д. А. Тарбаева¹  Т. Е. Белокриницкая¹ 

[1] ГБОУ ВПО «Читинская государственная медицинская академия» Минздрава России

关键词: генетический полиморфизм;    гемостаз;    грипп A(H1N1)pdm09;    беременность;   

DOI  :  

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Polymorphisms of gene-candidates of hemostasis disorder (F2:20210 G>A, F5:1691 G>A, F7:10976 G>A, F13:103 G>T, FGB:455 G>A, ITGA2:807 C>T, ITGB3:1565 T>C, PAI-1:675 5G>4G) and frequency of 14 groups of alleles of the HLA-DRB1 locus were study in women, suffered from flu А(H1N1)pdm09 during pregnancy. Significant association between heterozygotes genotype F7: 0976G/A and complicated forms of influenza was found (OR = 1,5). Mutant homozygotes with PAI-1:675 4G/4G genotype also had high risk of severe complicated influenza A(H1N1) (OR = 1,5). Genotypes HLA DRB1*07*15 and DRB1*16*16 were associated with complicated influenza. We assume, that сombined F7:0976GA, PAI-1:6754G4G and HLA DRB1*07*15, *16*16, DRB1*01*01 genotypes may be genetic predictor of severe complicated flu А(H1N1)pdm09 in pregnancy.

【 授权许可】

CC BY