Enhancing Osseointegration of Orthopaedic Implants with Titania Nanotube Surfaces:

Foot & Ankle Orthopaedics

AlexanderVara¹ 

关键词: Bone ingrowth;    Osseointegration;    Titania nanotubes;   

DOI  :  10.1177/2473011416S00177

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Category:Basic Sciences/BiologicsIntroduction/Purpose:Solid biologic fixation at the bone-implant interface provides long-term stability of orthopaedic implants. Historically, coatings and surface treatments on implant surfaces have been used to promote osseointegration of orthopaedic implants. The purpose of this research study is to evaluate two morphologies of titania nanotube (TiNT) surfaces via in vitro experiments as well as an in vivo model of femoral intramedullary fixation, in order to assess the influence of TiNT structure on de novo bone formation and bone-implant stability.Methods:TiNT structures were grown from Ti-6Al-4 V materials via an established electrochemical anodization process. Samples were either sonicated then annealed (Aligned TiNT) or annealed without prior sonication (Trabecular TiNT), to produce different morphologies. As-received titanium alloy was the control. Marrow-derived stem cells were isolated from long bones of Sprague Dawley rats and cultured on samples. Alkaline phos...

【 授权许可】

CC BY