Adult Astrogenesis and the Etiology of Cortical Neurodegeneration:

Journal of Experimental Neuroscience

Tal C.Mohn¹ 

关键词: astrocyte;    gliogenesis;    neurogenesis;    gliosis;    Alzheimer's disease;    dementia with Lewy bodies;   

DOI  :  10.4137/JEN.S25520

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

As more evidence points to a clear role for astrocytes in synaptic processing, synaptogenesis and cognition, continuing research on astrocytic function could lead to strategies for neurodegenerative disease prevention. Reactive astrogliosis results in astrocyte proliferation early in injury and disease states and is considered neuroprotective, indicating a role for astrocytes in disease etiology. This review describes the different types of human cortical astrocytes and the current evidence regarding adult cortical astrogenesis in injury and degenerative disease. A role for disrupted astrogenesis as a cause of cortical degeneration, with a focus on the tauopathies and synucleinopathies, will also be considered.

【 授权许可】

CC BY