Hydroxyurea Induces p53 Accumulation and Apoptosis in Human Cervical Carcinoma Cells

Turkish Journal of Biology

HAKAN AKÇA¹ 

关键词: Hydroxyurea;    p53;    p21;    Cervical Carcinoma;    DNA fragmentation;    Apoptosis;   

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

Cervical carcinoma is one type of cancer with a high mortality rate in women. In this research, we investigated the cytotoxic, antiproliferative and apoptosis-inducing effects of hydroxyurea on a human cervical carcinoma cell line, HeLa. We found that hydroxyurea has cytotoxic and antiproliferative effects on HeLa cells in a dose-dependent manner. We also found that hydroxyurea can increase cellular levels of p53 and p21, and induce DNA fragmentation in a dose-dependent manner. We concluded that the observed antiproliferative, cytotoxic and apoptosis inducing activities of hydroxyurea might be mediated by the induction of p53 and its transcriptional target, p21.

【 授权许可】

Unknown