The Use of a Cellular Bone Allograft Containing Multipotent Adult Progenitor Cells for Foot and Ankle Arthrodeses:

Foot & Ankle Orthopaedics

Samuel B.Adams, Jr¹ 

关键词: arthrodesis;    fusion;    cellular bone graft;    multipotent adult progenitor cells;    mesenchymal stem cells;    autograft;    allograft;   

DOI  :  10.1177/2473011416S00309

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Category:Basic Sciences/BiologicsIntroduction/Purpose:Arthrodesis procedures are commonplace in foot and ankle surgery. Unfortunately, nonunion rates have been reported to be as high as 40%. To combat nonunion, autograft bone is often used but has been associated with morbidity and poor cell quality. Therefore, the use of cellular bone allograft (CBA) has become commonplace. Traditional CBAs are osteoconductive, osteoinductive and the cellular component is typically osteogenic but not angiogenic. The added property of angiogenesis may be beneficial in achieving fusion. The purpose of this study was to determine the efficacy of a CBA composed of MAPC-class cells that have both osteogenic and angiogenic properties.Methods:The CBA (map3, RTI Surgical, Alachua, FL) was used in 41 distinct foot and ankle arthrodesis sites in 37 consecutive patients with a mean age of 52 years (range, 19-88). In all cases the graft was interposed between the prepared bone surfaces prior to hardware placement. All patients were ...

【 授权许可】

CC BY