Prefrontal Cortex in Learning to Overcome Generalized Fear:

Journal of Experimental Neuroscience

EdwardKorzus¹ 

关键词: fear discrimination;    prefrontal cortex;    overgeneralization;    NMDA Receptor;    CBP;   

DOI  :  10.4137/JEN.S26227

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Normal brain functioning relies critically on the ability to control appropriate behavioral responses to fearful stimuli. Overgeneralized fear is the major symptom of anxiety disorders including posttraumatic stress disorder. This review describes recent data demonstrating that the medial prefrontal cortex (mPFC) plays a critical role in the refining of cues that drive the acquisition of fear response. Recent studies on molecular mechanisms that underlie the role of mPFC in fear discrimination learning are discussed. These studies suggest that prefrontal N-methyl-D-aspartate receptors expressed in excitatory neurons govern fear discrimination learning via a mechanism involving cAMP response element-binding protein-dependent engagement of acetyltransferase.

【 授权许可】

CC BY