Concise synthesis of pyrrolo[2,3-d]pyrimidine derivatives via the Cu-catalyzed coupling reaction

Green Chemistry Letters and Reviews

Leilei Wang¹ 

关键词: Pyrrolo[2;    3-d]pyrimidine;    Cu catalyst;    heterocycles;    synthesis;   

DOI  :  10.1080/17518253.2016.1275822

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

We reported a green and simple Cu-catalyzed method for the efficient synthesis of 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide as the key intermediate in the synthetic approaches to pyrrolo[2,3-d]pyrimidine derivatives from 5-bromo-2,4-dichloropyrimidine through two routes in four steps and five steps, respectively. This method provided green and economical approaches toward numerous pyrrolo[2,3-d]pyrimidine derivatives.

【 授权许可】

Unknown