Successful allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in a patient with severe aplastic anemia and active infection

Tzu-Chi Medical Journal

Tso-Fu Wang¹ 

关键词: Hematopoietic stem cell transplantation;    Infection;    Reduced intensity conditioning;    Severe aplastic anemia;   

DOI  :  

学科分类：医学（综合）

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Infection is the major cause of mortality in patients with severe aplastic anemia (SAA) and often results in postponement of immunotherapy or transplantation treatment. We report on a 23-year-old man with very SAA with almost no neutrophils who was primarily treated with peripheral blood stem cell transplantation from an HLA-identical sibling. He received reduced dose conditioning with cyclophosphamide and antithymocyte globulin during active infection with typhlitis and pneumonia. Cyclophosphamide 50 mg/kg/d was given on Day 4 and Day 3 before transplantation and antithymocyte globulin Fresenius 20 mg/kg/d was given on Day 3 and Day 2. Neutrophils and platelets were engrafted on Day +18 and Day +20 after transplantation. Symptoms and signs of acute or chronic graft versus host disease were not observed as of Day +545 after transplantation. Allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning may be considered as the primary therapy for SAA complicated by severe infection.

【 授权许可】

CC BY-NC-SA