One pot synthesis of unsymmetrical dihydropyridines by green, catalyst free and environmentally benign protocol

Green Chemistry Letters and Reviews

Papori Goswami¹ 

关键词: β-enamino esters;    β-keto esters;    dihydropyridines;    α;    β-unsaturated carbonyl compounds;    reflux;   

DOI  :  10.1080/17518250802403774

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

A facile and ecofriendly synthesis of β-enamino esters is reported by reaction of both aliphatic and aromatic amines with β-keto esters by refluxing in ethanol in absence of any catalyst. Addition of α,β-unsaturated aldehydes to the reaction mixture leads to the formation of unsymmetrical dihydropyridine derivatives which generally are metal free hydrogen sources for asymmetric reduction reactions.

【 授权许可】

Unknown