PEG 400 promoted nucleophilic substitution reaction of halides into organic azides under mild conditions

Green Chemistry Letters and Reviews

Hongyao Zeng¹ 

关键词: polyethylene glycol 400;    nucleophilic substitution reaction;    halide;    azide;   

DOI  :  10.1080/17518253.2011.571717

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

Polyethylene glycol 400 (PEG 400) has been demonstrated as an efficient and eco-friendly reaction medium for the preparation of organic azides from structurally diverse halides by nucleophilic substitution reaction with NaN3 under mild conditions. The advantages of this protocol are: operational simplicity, environmental safety, broad substrate scope, excellent functional group tolerance, and short reaction time. The PEG 400 can be recovered and reused.

【 授权许可】

Unknown