Autism: Metabolism, Mitochondria, and the Microbiome:

Global Advances in Health and Medicine

DerrickMacfabe¹ 

关键词: Autism spectrum disorder;    propionic acid;    propanoic acid;    microbiome;    gastrointestinal tract;    mitochondria;    carnitine;    gap junctions;    fatty acids;    clostridia;    neuropsychiatric disorder;    animal model;   

DOI  :  10.7453/gahmj.2013.089

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

New approaches are needed to examine the diverse symptoms and comorbidities of the growing family of neurodevelopmental disorders known as autism spectrum disorder (ASD). ASD originally was thought to be a static, inheritable neurodevelopmental disorder, and our understanding of it is undergoing a major shift. It is emerging as a dynamic system of metabolic and immune anomalies involving many organ systems, including the brain, and environmental exposure. The initial detailed observation and inquiry of patients with ASD and related conditions and the histories of their care-givers and families have been invaluable. How gastrointestinal (GI) factors are related to ASD is not yet clear. Nevertheless, many patients with ASD have a history of previous antibiotic exposure or hospitalization, GI symptoms, abnormal food cravings, and unique intestinal bacterial populations, which have been proposed to relate to variable symptom severity.

【 授权许可】

CC BY