Multistep soluble polymer-supported, microwave-assisted synthesis of quinoxalines

Green Chemistry Letters and Reviews

Farid Fouad¹ 

关键词: quinoxalines;    microwave organic synthesis;    liquid-phase synthesis;    polymer-supported synthesis;   

DOI  :  10.1080/17518253.2013.772245

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

A multistep liquid-phase, polymer-supported, microwave-assisted synthesis of quinoxalines on polyethylene glycol, PEG-4500, is demonstrated. The usage of microwave energy to accelerate organic reactions reduces reaction time from hours (under reflux) to only minutes. The solution-phase chemistry on soluble polyethylene glycol, PEG, support facilitates the use of microwave energy (since PEG easily absorbs microwaves) and avoids the silica gel chromatography purifications of intermediate compounds, supporting parallel, combinatorial, and ultimately automated syntheses.

【 授权许可】

Unknown