Scanning electron microscopical observation of an osteoblast/osteoclast co-culture on micropatterned orthopaedic ceramics:

Foot & Ankle Orthopaedics

MansurHalai¹ 

关键词: Micropattern;    Ceramics;    Osteointegration;   

DOI  :  10.1177/2473011418S00238

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Category:Basic Sciences/BiologicsIntroduction/Purpose:In biomaterial engineering, the surface of an implant can influence cell differentiation, adhesion and affinity towards the implant. On contact with an implant, bone marrow-derived mesenchymal stromal cells (BMSCs) demonstrate differentiation towards bone forming osteoblasts, which can improve osteointegration. The process of micropatterning has been shown to improve osteointegration in polymers, but there are few reports surrounding ceramics. Several implants in forefoot surgery like the Moje metatarsal phalangeal joint replacement were made from smoother ceramic zirconia toughened alumina (ZTA).The aim was to establish whether the pits were specifically bioactive towards osteogenesis or were generally bioactive and would also stimulate osteoclastogenesis that could potentially lead to osteolysis.Methods:We established a co-culture of bone marrow-derived mesenchymal stromal cells (BMSCs) with osteoclast progenitor cells and to observe the response to ...

【 授权许可】

CC BY