Effects of Micronized Cartilage Matrix on Cartilage Repair in Osteochondral Lesions of the Talus:

Foot & Ankle Orthopaedics

ChristopherKreulen¹ 

关键词: osteochondral lesion;    talus;    OLT;    biocartilage;    OCD;   

DOI  :  10.1177/2473011417S000055

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Category:Ankle, Arthroscopy, SportsIntroduction/Purpose:A promising new technique in the treatment of osteochondral lesions of the talus (OLT) involves the use of an acellular micronized cartilage matrix (MCM), BioCartilage, to fill the lesions. The micronized cartilage matrix is thought to improve the production of hyaline-like cartilage by resident cells in a cartilage defect, but its effect on bone marrow cells remains untested. Here we hypothesized that adding bone-marrow derived stem cells to the BioCartilage would result in the chondrogenic differentiation of the stem cells. We designed an in-vitro model to mimic the clinical situation to determine if the combination of MCM and human bone marrow derived mesenchymal stem cells (MSCs) would produce a hyaline-like cartilage in- vitro to ultimately provide a reliable, one-step treatment for osteochondral lesions in the talus.Methods:Human bone marrow-derived stem cells were obtained from consented patients and expanded in monolayer culture using standar...

【 授权许可】

CC BY