Glial Tau Pathology in Tauopathies: Functional Consequences:

Journal of Experimental Neuroscience

Martha A.Kahlson¹ 

关键词: tau;    tauopathy;    glial tau pathology;    functional consequences;    neurodegeneration;    astrocytes;    oligodendrocytes;    microglia;   

DOI  :  10.4137/JEN.S25515

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells. Though the ratio of neuronal and glial tau aggregates varies across diseases, glial tau aggregates can populate the same degenerating brain regions as neuronal tau aggregates. While much is known about the deleterious consequences of tau pathology in neurons, the relative contribution of glial tau pathology to these diseases is less clear. Recent studies using a number of model systems implicate glial tau pathology in contributing to tauopathy pathogenesis. This review aims to highlight the functional consequences of tau overexpression in glial cells and explore the potential contribution of glial tau pathology in the pathogenesis of neurodegenerative tauopathies.

【 授权许可】

CC BY