Роль нарушений состава фосфолипидов в патогенезе цитомегаловирусной инфекции в период гестации

Acta Biomedica Scientifica

Н. А. Ишутина¹ 

[1] ФГБНУ «Дальневосточный научный центр физиологии и патологии дыхания»

关键词: фосфолипиды;    фосфолипаза А<;    sub>;    2<;    /sub>;    беременность;    цитомегаловирусная инфекция;    фосфолипиды;    фосфолипаза А<;    sub>;    2<;    /sub>;    беременность;    цитомегаловирусная инфекция;   

DOI  :  

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

We studied the composition of phospholipids and phospholipase A 2in 96 pregnant women c cytomegalovirus infection (titer of IgG antibodies to cytomegalovirus 1 : 1600). It was found that the aggravation of CMV infection in pregnant women is accompanied with membrane-destructive phenomena, which are based on the activation of phospholipase A 2and the modification of the phospholipid matrix exhibits decrease of phosphatidylethanolamine (I trimester - by 24%, II trimester - by 16 %, III trimester - by 9 % (p < 0,001)); phosphatidylcholine (I trimester - by 14 %, II trimester - by 16 %, III trimester - 23 % (p < 0,001)); phosphatidylserine (I trimester - by 46 % (p < 0,001), II trimester - by 33 % (p < 0,01), III trimester - by 101 % (p < 0,001)). Increasing the concentration of sphingomyelin (I trimester - by 16 %, II and III trimesters - by 9 %; p < 0,001), lysophosphatidylcholine (I trimester - by 71 %, II trimester - 59 %, III trimester - by 51 % (p < 0,001)) compared with healthy women. Identified changes may be the significant factor in violation of the deformability of cells, red blood cell hemolysis, increased microviscosity blood, and therefore is the cause of fetal hypoxia.

【 授权许可】

CC BY