A novel multicomponent reaction between amino acids, aromatic aldehydes and p-toluenesulfonylmethyl isocyanide: an efficient and green one-pot synthesis using nanosilica

Green Chemistry Letters and Reviews

Ladan Edjlali¹ 

关键词: Ugi reaction;    tosyl acyloxy amino carboxamide derivatives;    amino acid;    aromatic aldehydes;    toluenesulfonylmethyl isocyanide;    silica nanoparticles;   

DOI  :  10.1080/17518253.2015.1116617

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

The novel diastereomeric sulfonylamide derivatives 4a–h were synthesized by multi-component reactions between (l)-α-amino acids, 1, aromatic aldehydes, 2 and p-toluenesulfonylmethyl isocyanide, 3 in water/methanol using nanosilica as a catalyst. The one-pot green reactions were carried out at room temperature with a quantitative yield in water/methanol. The yield of the reactions and products was determined and discussed. The reusablity of the catalyst is discussed.

【 授权许可】

Unknown