Global & Regional Health Technology Assessment | |
Cost-effectiveness analysis of paliperidone palmitate versus long-acting risperidone as maintenance treatment in schizophrenia patients in Italy: | |
RobertoRavasio1  | |
关键词: Paliperidone palmitate; cost-effectiveness; schizophrenia; QALY; | |
DOI : 10.5301/GRHTA.5000186 | |
学科分类:医学(综合) | |
来源: Sage Journals | |
【 摘 要 】
ObjectiveTo evaluate the cost-effectiveness of paliperidone palmitate (paliperidone long-acting injectable; PP) compared with long-acting injectable risperidone (RRP) in multi-episode patients (two or more relapses) with schizophrenia in Italy.MethodsA pre-existing Markov model was utilized to simulate the history of a cohort of multi-episode patients transitioning through different health states on a monthly basis over a 12 or 24 month horizon from the perspective of the Italian National Health Service. Therapeutic strategies consisted of treatment with long-acting injectable risperidone (mean dose 37.5 mg every 2 weeks) or paliperidone palmitate (mean dose 75 mg equivalent [eq.] every month). Probability of relapse, level of adherence, side effects (extrapyramidal symptoms, tardive dyskinesia, weight gain and diabetes) and treatment discontinuation (switch) were derived from long-term observational data when feasible. The cost-effectiveness analysis considered quality adjusted life-years (QALYs) and dir...
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201901210689041ZK.pdf | 2363KB | download |