Associations of Oxidative Phosphorylation–Related Genes With Deep Intracerebral Hemorrhage in Taiwan:

Journal of Experimental Neuroscience

Yi-ChunChen¹ 

关键词: Intracerebral hemorrhage;    oxidative phosphorylation;    polymorphism;    stroke;    association study;   

DOI  :  10.1177/1179069518794517

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Background:Pathway analysis demonstrated associations between deep intracerebral hemorrhage (DICH) and the genetic risk score of complex IV of the oxidative phosphorylation (OXPHOS) pathway in whites. This study investigated the related genetic variations in the DICH population in Taiwan. Candidate variants were selected from the prior report by the following criteria: (1) nuclear genes encoding mitochondria complex IV, (2) genetic effect >1.08, (3) global minor allele frequency >0.01. Six single-nucleotide polymorphisms fitted in the selection criteria, which were mainly involved in Cox assembly, including Cox10, Cox15, and Cox18, and one structural gene, Cox7C. Associations were tested with adjustment of multiple covariables. Permutation testing of 1000 replicates was performed for empirical estimates.Results:This study enrolled 336 patients and 379 controls. Compared with whites, the Taiwan population has higher minor allele frequency (MAF) of rs4308511, rs767844, and rs221592 and lower MAF of rs807964...

【 授权许可】

CC BY