Identity crisis in pulmonary arterial hypertension:

Pulmonary Circulation

G.Ruffenach¹ 

关键词: pulmonary hypertension;    cancer hallmarks;    tissues-specific gene;    Darwinian evolution;   

DOI  :  10.1177/2045893217746054

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes.

【 授权许可】

CC BY