Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit:

Journal of Experimental Neuroscience

LeiLi¹ 

关键词: Locus coeruleus;    superior colliculus;    stress;    looming;    norepinephrine;    defensive circuitry;    modulation;   

DOI  :  10.1177/1179069518792035

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Among key survival circuits, defensive response circuits are one of the most intensively studied. A consensus is emerging that multiple, independent circuitries are involved in different conditioned and unconditioned defensive responses. Investigating these well-conserved defensive responses would help us to decipher the basic working mechanism of the brain at a circuitry level and thus shed light on new diagnoses and treatments for neural diseases and disorders. We showed that the visually evoked innate defensive response was modulated by a locus coeruleus-superior colliculus (LC-SC) projection. Our work demonstrates that as conserved and instinctive as the survival circuits are, they are flexible and subject to fine-tuned modulation by experience or internal states of the animals. Here, we provide more data to further discuss the possible downstream mechanisms of the LC-SC pathway for this important modulation of the defensive response, the wide range of flight latency between individual flight responses, and the interpretations of our data with additional statistical analysis.

【 授权许可】

CC BY