The bacteria Wolbachia in filariae, a biological Russian dolls’ system: new trends in antifilarial treatments

Parasite

and L. Gavotte²  C. Martin¹ 

[1] INSERM, USM 307, Parasitologie comparée et Modèles expérimentaux, Muséum national d’Histoire naturelle, 61, rue Buffon,CP52,Paris Cedex 05,France;ISEM, UMR CNRS 5554, Université Montpellier 2, place eugène Bataillon,34095,Montpellier,France

关键词: antibiotherapy;    symbiosis;    filaires;    Onchocercidae;    Wolbachia;   

Others  :  808330
DOI  :  doi:10.1051/parasite/2010172079

 received in 2010-02-23, accepted in 2010-03-18,  发布年份 2010

【 摘 要 】

Filarial nematode species can host Wolbachia bacterial endosymbionts. To understand the symbiosis, a higher level of complexity should be considered, taking in account the tripartite association between Wolbachia, filariae and mammals. This overview article discusses the biology of Wolbachia in filariae, including their distribution and phylogeny, mechanisms of action, inflammatory consequences on mammal host and biological control implications for filariases. Potential directions for future research are also discussed.

【 授权许可】

   
© PRINCEPS Editions, Paris, 2010